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Oxidation of the cyanobactin precursor peptide Is independent of the leader peptide and operates in a defined order

Abstract:

The five-membered nitrogen plus heteroatom rings known as azolines or in their oxidized form as azoles are very common in natural products and drugs. The oxidation of thiazoline to thiazole in the cyanobactin class of natural products is one of the several important transformations that are known to alter the biological properties of the compound. The ordering of the various chemical reactions that occur during cyanobactin biosynthesis is not fully understood. The structure of the flavin-depe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.biochem.8b00835

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0001-6744-5061
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/M028461/1
Publisher:
American Chemical Society
Journal:
Biochemistry More from this journal
Volume:
57
Issue:
41
Pages:
5996-6002
Publication date:
2018-10-18
Acceptance date:
2018-10-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Pmid:
30208270
Language:
English
Pubs id:
pubs:919703
UUID:
uuid:1b2eadd1-eb51-48a4-8a5c-9dc802f8ce0c
Local pid:
pubs:919703
Source identifiers:
919703
Deposit date:
2019-05-06

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