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Placental capillary pericytes release more exosomes and immunomodulatory and growth factors in response to hypoxia

Abstract:

Excess hypoxia can lead to developmental abnormalities and antenatal deficits such as fetal intrauterine growth restriction and preeclampsia. Capillary pericytes are multifunctional cells wrapped around the vascular endothelium that play essential roles in vascular development and blood flood regulation. In vivo, brain pericytes respond to hypoxia by irreversibly constricting capillaries and thus causing cell death in rigor. To date, placental capillary pericytes (PLVP) have not been fully ch...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More from this funder
Name:
Oxfordshire Health Service Research Comm
Grant:
EC/1152
More from this funder
Name:
Medical Research Council
Grant:
MR/J003360/1
More from this funder
Name:
Wellcome Trust
Grant:
105605/Z/14/Z
Publisher:
Elsevier
Host title:
Placenta
Journal:
International Federation of Placenta Associations Meeting (IFPA 2018) More from this journal
Volume:
69
Issue:
6
Pages:
E75-E76
Publication date:
2018-09-10
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
Pubs id:
pubs:921713
UUID:
uuid:1b01131f-37c2-401b-bb0c-7b266f7c688b
Local pid:
pubs:921713
Source identifiers:
921713
Deposit date:
2018-10-02

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