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Myofibroblast migration and signaling in in vitro colorectal cancer models

Abstract:

Colorectal cancer is one of the most prevalent, and one of the deadliest, types of cancer in the world. The colonic epithelium is positioned atop a subepithelial structure consisting of extracellular matrix and stromal cells, and colorectal tumors closely interact with this tissue. Myofibroblasts make up the primary cellular component of the subepithelial stroma in the colon, and play important roles in the maintenance of the normal colonic stem cell niche. Increased recruitment of local m...

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Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
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