Journal article
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons
- Abstract:
-
Human induced pluripotent stem cells (hiPSCs) have become indispensable for disease modelling. They are an important resource to access patient cells harbouring disease-causing mutations. Derivation of midbrain dopaminergic (DAergic) neurons from hiPSCs of PD patients represents the only option to model physiological processes in a cell type that is not otherwise accessible from human patients. However, differentiation does not produce a homogenous population of DA neurons and contaminant cel...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Stem Cell Research Journal website
- Volume:
- 41
- Article number:
- 101656
- Publication date:
- 2019-11-09
- Acceptance date:
- 2019-11-08
- DOI:
- EISSN:
-
1876-7753
- ISSN:
-
1873-5061
- Pmid:
-
31733438
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1072930
- UUID:
-
uuid:1abfaaf6-b9fb-4297-bb5c-b7dae7accd1c
- Local pid:
- pubs:1072930
- Source identifiers:
-
1072930
- Deposit date:
- 2019-11-27
Terms of use
- Copyright holder:
- Überbacher et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. Published by Elsevier B.V. This is an open access article published under CC BY 4.0.
- Licence:
- CC Attribution (CC BY)
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