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Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

Abstract:

Human induced pluripotent stem cells (hiPSCs) have become indispensable for disease modelling. They are an important resource to access patient cells harbouring disease-causing mutations. Derivation of midbrain dopaminergic (DAergic) neurons from hiPSCs of PD patients represents the only option to model physiological processes in a cell type that is not otherwise accessible from human patients. However, differentiation does not produce a homogenous population of DA neurons and contaminant cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.scr.2019.101656

Authors


Publisher:
Elsevier
Journal:
Stem Cell Research More from this journal
Volume:
41
Article number:
101656
Publication date:
2019-11-09
Acceptance date:
2019-11-08
DOI:
EISSN:
1876-7753
ISSN:
1873-5061
Pmid:
31733438
Language:
English
Keywords:
Pubs id:
pubs:1072930
UUID:
uuid:1abfaaf6-b9fb-4297-bb5c-b7dae7accd1c
Local pid:
pubs:1072930
Source identifiers:
1072930
Deposit date:
2019-11-27

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