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Vaccine‐induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies

Abstract:

Secretory IgA (SIgA) is widely held to be responsible for the defense of the mucosae against pathogenics and other potentially harmful agents. In this study, polymeric Ig receptor (pIgR) knockout mice, which lack secretory antibodies (SAb), were used to investigate the role of vaccine-elicited SAb in protection against gastrointestinal bacterial infections. An essential role for specific SAb in protection against Vibrio cholerae was evident from experiments showing that vaccinated pIgR(-/-) m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.200425492

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
Wiley
Journal:
European Journal of Immunology More from this journal
Volume:
35
Issue:
1
Pages:
180-188
Publication date:
2005-01-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pmid:
15593123

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