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Histone deacetylation promotes transcriptional silencing at facultative heterochromatin

Abstract:

It is important to accurately regulate the expression of genes involved in development and environmental response. In the fission yeast Schizosaccharomyces pombe, meiotic genes are tightly repressed during vegetative growth. Despite being embedded in heterochromatin these genes are transcribed and believed to be repressed primarily at the level of RNA. However, the mechanism of facultative heterochromatin formation and the interplay with transcription regulation is not understood. We show gen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gky232

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Funding agency for:
Vasilieva, L
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Grant:
Research and Career Development
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
46
Issue:
11
Pages:
5426–5440
Publication date:
2018-03-29
Acceptance date:
2018-03-19
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:830751
URN:
uri:1aa8c035-5eef-4c45-8f6c-62e58e2ce9bb
UUID:
uuid:1aa8c035-5eef-4c45-8f6c-62e58e2ce9bb
Local pid:
pubs:830751

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