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25-hydroxy- and 1α,25-dihydroxycholecalciferol have greater potencies than 25-hydroxy- and 1α,25-dihydroxyergocalciferol in modulating cultured human and mouse osteoblast activities

Abstract:

Despite differences in the phamacokinetics of 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2) in man, the effects of these and their 1α-hydroxylated forms (1,25(OH)2D3 and 1,25(OH)2D2) on cellular activity of vitamin D-responsive cells have hardly been compared. We studied differences in the effects of these metabolites on cell number, gene transcription, protein expression and mineralisation of cultured human bone marrow-derived stromal cells (hBMSC) and rapidly ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0165462

Authors


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ORCID:
0000-0002-2922-3473
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Botnar Research Centre
Oxford college:
St Hildas College
ORCID:
0000-0002-4994-2264
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Botnar Research Centre
Oxford college:
Wadham College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
Botnar Research Centre
Oxford college:
Somerville College
ORCID:
0000-0001-7985-0048
Morovat, A More by this author
National Institute for Health Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
11
Pages:
e0165462
Publication date:
2016-11-28
Acceptance date:
2016-10-12
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Pubs id:
pubs:663831
URN:
uri:1a909fce-88f2-41cd-a9c9-4c1ebd86ea38
UUID:
uuid:1a909fce-88f2-41cd-a9c9-4c1ebd86ea38
Local pid:
pubs:663831

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