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Characterisation of novel phosphorylation sites on FANCD2 and their role in the Fanconi anaemia pathway

Abstract:

Interstrand crosslinks (ICLs) are a highly deleterious form of DNA damage because they link the two strands of DNA, blocking replication, transcription and chromosome segregation. At the center of ICL repair is the FANCD2/FANCI complex, recruitment of which onto the ICL is a critical step for repair. Monoubiquitination of both FANCD2 and FANCI lead to their retention on chromatin and is essential for subsequent repair. However, recent evidence shows that FANCD2 monoubiquitination takes pla...

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Division:
MSD
Department:
Biochemistry
Department:
Biochemistry
Role:
Author

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Department:
Biochemistry
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1a749320-e434-41e3-8b5d-32c5481c0dee
Language:
English
Subjects:

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