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The impact of genetic variation on IFITM3 related influenza virus restriction

Abstract:

The IFITM3 protein is a prominent restriction factor of influenza virus that has been shown to antagonise the cellular entry of influenza virus. In 2012, the minor allele of a synonymous SNP in IFITM3, known as rs12252 (major T, minor C), was shown to be associated with severe influenza virus infection. Numerous studies have corroborated this association, showing clear links between the C allele and increased risk of severe influenza virus infection in East Asian and European populations. ...

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University of Oxford
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Department:
University of Oxford
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Department:
University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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