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Thesis

Towards improved blood-stage malaria vaccines: characterising the underlying immunogenicity of vaccine adjuvants and vectors

Abstract:

The vaccine field generally accepts that the induction of high-titre antibodies will be necessary to prevent the invasion of erythrocytes utilising vaccines targeting the blood-stage of malaria. Protein-in-adjuvant formulations are commonly used to achieve such responses. However, their clinical development can be limited by the reactogenicity of some of the most potent pre-clinical adjuvants and the cost and complexity of licensing new adjuvants for human use. Work in this thesis describe...

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Institution:
University of Oxford
Research group:
Jenner Institute
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of

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Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Language:
English
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