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Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics

Abstract:

The incidence of Plasmodium vivax infection has declined markedly in Malaysia over the past decade despite evidence of high-grade chloroquine resistance. Here we investigate the genetic changes in a P. vivax population approaching elimination in 51 isolates from Sabah, Malaysia and compare these with data from 104 isolates from Thailand and 104 isolates from Indonesia. Sabah displays extensive population structure, mirroring that previously seen with the emergence of artemisinin-resistant P. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-04965-4

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Big Data Institute
ORCID:
0000-0002-4638-536X
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ORCID:
0000-0002-4313-4290
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Human Genetics Wt Centre
ORCID:
0000-0001-8060-6771
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Big Data Institute
ORCID:
0000-0002-7386-3566
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Big Data Institute
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Funding agency for:
Kwiatkowski, DP
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Funding agency for:
Kwiatkowski, DP
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Funding agency for:
Price, RN
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature communications Journal website
Volume:
9
Issue:
1
Publication date:
2018-07-03
Acceptance date:
2018-06-01
DOI:
EISSN:
2041-1723
Pubs id:
pubs:864588
URN:
uri:19e34169-3f80-4731-b5e3-dd6448bb2865
UUID:
uuid:19e34169-3f80-4731-b5e3-dd6448bb2865
Local pid:
pubs:864588
Language:
English
Keywords:

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