Journal article
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies
- Abstract:
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Clinical and neuropathological similarities between dementia with Lewy bodies (DLB), Parkinson's and Alzheimer's diseases (PD and AD, respectively) suggest that these disorders may share etiology. To test this hypothesis, we have performed an association study of 54 genomic regions, previously implicated in PD or AD, in a large cohort of DLB cases and controls. The cohort comprised 788 DLB cases and 2624 controls. To minimize the issue of potential misdiagnosis, we have also performed the ana...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 604.7KB, Terms of use)
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- Publisher copy:
- 10.1093/hmg/ddu334
Authors
Funding
+ Medical Research Council
More from this funder
Grant:
G0701075
MC_G1000735
MR/L010305/1
MR/L016397/1
MR/L022656/1
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Human Molecular Genetics More from this journal
- Volume:
- 23
- Issue:
- 23
- Pages:
- 6139-6146
- Publication date:
- 2014-06-27
- Acceptance date:
- 2014-06-24
- DOI:
- EISSN:
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1460-2083
- ISSN:
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0964-6906
- Pmid:
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24973356
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:475671
- UUID:
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uuid:19c99f9a-4c1d-4939-9665-4a8853f77c29
- Local pid:
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pubs:475671
- Source identifiers:
-
475671
- Deposit date:
-
2018-05-31
Terms of use
- Copyright holder:
- Bras et al
- Copyright date:
- 2014
- Notes:
- © The Author 2014. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
- Licence:
- CC Attribution (CC BY)
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