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Genetically determined levels of circulating cytokines and risk of stroke: role of monocyte chemoattractant protein-1

Abstract:

Background: Cytokines and growth factors have been implicated in the initiation and propagation of vascular disease. Observational studies have shown associations of their circulating levels with stroke. Our objective was to explore whether genetically determined circulating levels of cytokines and growth factors are associated with stroke and its etiologic subtypes by conducting a 2-sample Mendelian randomization (MR) study.

Methods: Genetic instruments for 41 cytokines and growth ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/circulationaha.118.035905

Authors


Publisher:
American Heart Association
Journal:
Circulation More from this journal
Volume:
139
Issue:
2
Pages:
256-268
Publication date:
2018-09-26
Acceptance date:
2018-08-17
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Pmid:
30586705
Language:
English
Keywords:
Pubs id:
pubs:955063
UUID:
uuid:19c6f854-70f8-4623-91a3-a4875ed72e06
Local pid:
pubs:955063
Source identifiers:
955063
Deposit date:
2019-03-13

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