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Thesis

Systems-level analysis of the mitotic checkpoint

Abstract:

The mitotic checkpoint regulates a critical transition in the eukaryotic cell cycle. It delays exit from mitosis until all chromosomes have become bi-oriented. In spite of an impressive body of work uncovering mechanistic aspects of the mitotic checkpoint, a detailed understanding of how the mitotic checkpoint operates as a control system continues to evade us. Here, I present three systems-biological studies aimed at elucidating distinct aspects of the mitotic checkpoint control system.

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Department:
Doctoral Training (MPLS)
Role:
Author

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Department:
Biochemistry
Role:
Contributor, Supervisor
Department:
Biochemistry
Role:
Examiner
Type of award:
DPhil
Awarding institution:
University of Oxford

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