- Abstract:
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Mitochondria play a key role in common neurodegenerative diseases and contain their own genome: mtDNA. Common inherited polymorphic variants of mtDNA have been associated with several neurodegenerative diseases, and somatic deletions of mtDNA have been found in affected brain regions. However, there are conflicting reports describing the role of rare inherited variants and somatic point mutations in neurodegenerative disorders, and recent evidence also implicates mtDNA levels. To address thes...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.9MB)
-
- Publisher copy:
- 10.1186/s40478-016-0404-6
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- Publisher:
- BioMed Central Publisher's website
- Journal:
- Acta Neuropathologica Communications Journal website
- Volume:
- 5
- Issue:
- 1
- Pages:
- 13
- Publication date:
- 2017-02-05
- Acceptance date:
- 2016-12-13
- DOI:
- EISSN:
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2051-5960
- Pubs id:
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pubs:679680
- URN:
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uri:1990cd99-fe58-40b4-a967-22645150e5de
- UUID:
-
uuid:1990cd99-fe58-40b4-a967-22645150e5de
- Local pid:
- pubs:679680
- Language:
- English
- Keywords:
- Copyright holder:
- Turner et al
- Copyright date:
- 2017
- Notes:
- © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Journal article
Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.
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National Institute for Health Research
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University of Cambridge
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