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Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis?

Abstract:

There is a polygenic component to rheumatoid arthritis (RA) in addition to the known association with HLA-DR4. It has previously been shown in another autoimmune disease (type I diabetes mellitus) that a gene on chromosome 11p can act with HLA-DR4 to enhance susceptibility (relative risk 5-6). It is therefore possible that this locus may also affect the development of RA. Genotype frequencies at this locus, defined by a dimorphic Fok 1 restriction site, were compared in 139 healthy controls a...

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Publication status:
Published

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Publisher copy:
10.1136/ard.51.11.1250

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Publisher:
BMJ Publishing Group
Journal:
Annals of the rheumatic diseases
Volume:
51
Issue:
11
Pages:
1250-1251
Publication date:
1992-11-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:193752ba-9a15-4118-8201-033726462b5f
Source identifiers:
108628
Local pid:
pubs:108628

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