Journal article icon

Journal article

Vimentin restrains regulatory T-cell suppression of graft-versus-host disease

Abstract:

Regulatory T-cells (Treg) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for the augmentation of therapeutic efficacy. In contrast to activated conventional T-cells, where protein kinase C-T (PKC-T) localizes to the contact-point between T-cells and antigen-presenting cells, in Treg, PKC-T localizes to the opposite end of t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1172/JCI95713

Authors


Expand authors...
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
128
Issue:
10
Pages:
4604–4621
Publication date:
2018-08-14
Acceptance date:
2018-06-26
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pubs id:
pubs:871426
URN:
uri:192ce4ea-681f-4a0c-a15f-64e8b3b3bd89
UUID:
uuid:192ce4ea-681f-4a0c-a15f-64e8b3b3bd89
Local pid:
pubs:871426

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP