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Journal article

Vimentin restrains regulatory T-cell suppression of graft-versus-host disease

Abstract:

Regulatory T-cells (Treg) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for the augmentation of therapeutic efficacy. In contrast to activated conventional T-cells, where protein kinase C-T (PKC-T) localizes to the contact-point between T-cells and antigen-presenting cells, in Treg, PKC-T localizes to the opposite end of t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI95713

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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
128
Issue:
10
Pages:
4604–4621
Publication date:
2018-08-14
Acceptance date:
2018-06-26
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
871426
Pubs id:
pubs:871426
UUID:
uuid:192ce4ea-681f-4a0c-a15f-64e8b3b3bd89
Local pid:
pubs:871426
Deposit date:
2018-07-17

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