Journal article
Vimentin restrains regulatory T-cell suppression of graft-versus-host disease
- Abstract:
-
Regulatory T-cells (Treg) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for the augmentation of therapeutic efficacy. In contrast to activated conventional T-cells, where protein kinase C-T (PKC-T) localizes to the contact-point between T-cells and antigen-presenting cells, in Treg, PKC-T localizes to the opposite end of t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1172/JCI95713
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Authors
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Volume:
- 128
- Issue:
- 10
- Pages:
- 4604–4621
- Publication date:
- 2018-08-14
- Acceptance date:
- 2018-06-26
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- Source identifiers:
-
871426
Item Description
- Pubs id:
-
pubs:871426
- UUID:
-
uuid:192ce4ea-681f-4a0c-a15f-64e8b3b3bd89
- Local pid:
- pubs:871426
- Deposit date:
- 2018-07-17
Terms of use
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2018
- Notes:
- © 2018 American Society for Clinical Investigation.
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