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Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis

Abstract:

Background: Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, and the association of genetically predicted IGF-I with aggressive prostate cancer is not known. We aimed to investigate the associations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 concentrations with overall, aggressive and early-onset prostate ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ije/dyac124

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
ORCID:
0000-0002-5652-356X

Contributors

Publisher:
Oxford University Press
Journal:
International Journal of Epidemiology More from this journal
Volume:
52
Issue:
1
Pages:
71-86
Publication date:
2022-06-21
Acceptance date:
2022-05-26
DOI:
EISSN:
1464-3685
ISSN:
0300-5771
Language:
English
Keywords:
Pubs id:
1260402
Local pid:
pubs:1260402
Deposit date:
2022-05-23

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