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A systematic review and meta-analysis of the effectiveness of acetylcholinesterase inhibitors and memantine in treating the cognitive symptoms of dementia

Abstract:

Background: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the mini-mental state examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores.

Summary: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1159/000486546

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; CSM
ORCID:
0000-0001-6810-2845
Khondoker, M More by this author
Stewart, R More by this author
National Institute for Health Research More from this funder
Publisher:
Karger Publishers Publisher's website
Journal:
Dementia and Geriatric Cognitive Disorders Journal website
Volume:
45
Issue:
3-4
Pages:
131–151
Publication date:
2018-05-07
Acceptance date:
2017-12-31
DOI:
EISSN:
1421-9824
ISSN:
1420-8008
Pubs id:
pubs:825903
URN:
uri:18c9670b-05c8-45ce-a524-39bb7d2f237f
UUID:
uuid:18c9670b-05c8-45ce-a524-39bb7d2f237f
Local pid:
pubs:825903

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