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A note on statistical repeatability and study design for high-throughput assays

Abstract:

Characterizing the technical precision of measurements is a necessary stage in the planning of experiments and in the formal sample size calculation for optimal design. Instruments that measure multiple analytes simultaneously, such as in high-throughput assays arising in biomedical research, pose particular challenges from a statistical perspective. The current most popular method for assessing precision of high-throughput assays is by scatterplotting data from technical replicates. Here, we...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/sim.7175

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Department:
Oxford, MPLS, Statistics
Role:
Author
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Department:
St Annes College
Role:
Author
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
Statistics in Medicine Journal website
Volume:
36
Issue:
5
Pages:
790–798
Publication date:
2016-11-24
Acceptance date:
2016-10-28
DOI:
EISSN:
1097-0258
ISSN:
0277-6715
Pubs id:
pubs:663663
URN:
uri:18bc00b1-95ee-43bc-b0f3-6d7554849c09
UUID:
uuid:18bc00b1-95ee-43bc-b0f3-6d7554849c09
Local pid:
pubs:663663
Paper number:
5

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