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A note on statistical repeatability and study design for high-throughput assays

Abstract:

Characterizing the technical precision of measurements is a necessary stage in the planning of experiments and in the formal sample size calculation for optimal design. Instruments that measure multiple analytes simultaneously, such as in high-throughput assays arising in biomedical research, pose particular challenges from a statistical perspective. The current most popular method for assessing precision of high-throughput assays is by scatterplotting data from technical replicates. Here, we...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/sim.7175

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
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Institution:
University of Oxford
Oxford college:
St Anne's College
Role:
Author
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Funding agency for:
Holmes, C
Grant:
Programme Leaders award MC_UP_A390_1107
More from this funder
Funding agency for:
Holmes, C
Grant:
Programme Leaders award MC_UP_A390_1107
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
Statistics in Medicine Journal website
Volume:
36
Issue:
5
Pages:
790–798
Publication date:
2016-11-24
Acceptance date:
2016-10-28
DOI:
EISSN:
1097-0258
ISSN:
0277-6715
Source identifiers:
663663
Language:
English
Keywords:
Pubs id:
pubs:663663
UUID:
uuid:18bc00b1-95ee-43bc-b0f3-6d7554849c09
Local pid:
pubs:663663
Deposit date:
2017-01-05

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