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Thesis

The regulation and inhibition of P-TEFb

Abstract:

Correct regulation of transcription is essential for maintaining a healthy cellular state. During transcription RNA polymerase II (Pol II) proceeds in a regulated manner through several transitions to ensure appropriate control of synthesis and enable correct processing of the pre-RNA. Shortly after initiation Pol II is caused to pause by the binding of factors, DSIF and NELF. To enable transition of Pol II into the elongation phase CDK9/cyclin T phosphorylates the C-terminal domain (CTD)...

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Institution:
University of Oxford
Oxford college:
Queen's College, The
Department:
Medical Sciences Division - Biochemistry
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Alison Hole
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:18ba1399-e3db-4ed6-bd9b-019bbd3c0b65
Local pid:
ora:6334

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