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Journal article

Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane

Abstract:

Evidence supporting the heterogeneity in cAMP and PKA signaling is rapidly accumulating and has been largely attributed to the localization or activity of adenylate cyclases, phosphodiesterases, and A-kinase–anchoring proteins in different cellular subcompartments. However, little attention has been paid to the possibility that, despite homogeneous cAMP levels, a major heterogeneity in cAMP/PKA signaling could be generated by the spatial distribution of the final terminators of this cascade, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1806318115

Authors


Burdyga, A More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Di Benedetto, G More by this author
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
28
Pages:
E6497-E6506
Publication date:
2018-06-25
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:859880
URN:
uri:18804f1a-9bc1-443b-b751-a8b4619cdbc2
UUID:
uuid:18804f1a-9bc1-443b-b751-a8b4619cdbc2
Local pid:
pubs:859880
Language:
English
Keywords:

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