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Thesis

Insights from primary immunodeficiencies: investigating the role of GIMAP6 in the immune system

Abstract:

While molecular, cellular, and animal models play a vital role in immunological research, the study of patients with inborn errors of immunity provides a unique opportunity to elucidate the direct importance of specific genes in the human immune system. In this thesis, I have investigated the disease etiology of four sets of patients believed to have novel primary immunodeficiencies (PIDs) using whole exome sequencing coupled with in vitro and in vivo assays of both patient cells and model...

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Department:
Nuffield Department of Medicine and National Institute of Allergy and Infectious Diseases (National Institutes of Health)

Contributors

Department:
Nuffield Department of Medicine
Role:
Supervisor
Department:
Kennedy Institute of Rheumatology
Role:
Supervisor
Department:
National Institute of Allergy and Infectious Diseases (National Institutes of Health)
Role:
Supervisor
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Funding agency for:
Brittany Chao
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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