Journal article
Large-volume hyperthermia for safe and cost-effective targeted drug delivery using a clinical ultrasound-guided focused ultrasound device
- Abstract:
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Lyso-thermosensitive liposomes (LTSLs) are specifically designed to release chemotherapy agents under conditions of mild hyperthermia. Preclinical studies have indicated that magnetic resonance (MR)-guided focused ultrasound (FUS) systems can generate well-controlled volumetric hyperthermia using real-time thermometry. However, high-throughput clinical translation of these approaches for drug delivery is challenging, not least because of the significant cost overhead of MR guidance and the mu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 4.3MB, Terms of use)
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- Publisher copy:
- 10.1016/j.ultrasmedbio.2020.12.008
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Funding
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Ultrasound in Medicine and Biology More from this journal
- Volume:
- 47
- Issue:
- 4
- Pages:
- 982-997
- Publication date:
- 2021-01-13
- Acceptance date:
- 2020-12-10
- DOI:
- EISSN:
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1879-291X
- ISSN:
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0301-5629
- Pmid:
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33451816
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1157298
- Local pid:
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pubs:1157298
- Deposit date:
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2021-04-03
Terms of use
- Copyright holder:
- PC Lyon et al.
- Copyright date:
- 2021
- Rights statement:
- © 2020 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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