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The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial

Abstract:

Sodium nitroprusside (SNP) has been reported to rapidly reduce psychotic symptoms in patients with schizophrenia. This has the potential to revolutionize treatment for schizophrenia. In this study, we tested the hypothesis that SNP leads to a reduction in psychotic symptoms and an improvement in spatial working memory (SWM) performance in patients with schizophrenia.This was a single-centre, randomized, double-blind, placebo-controlled trial performed from 27 August 2014 to 10 February 2016 (...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1017/S0033291716002245

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Department:
Oxford, MSD, Psychiatry
Role:
Author
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Grant:
Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King’s College London
Publisher:
Cambridge University Press Publisher's website
Journal:
Psychological Medicine Journal website
Volume:
46
Issue:
16
Pages:
3443-3450
Publication date:
2016-09-22
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
Pubs id:
pubs:648027
URN:
uri:185cbc27-c6e9-40fd-95d6-61133dec7e34
UUID:
uuid:185cbc27-c6e9-40fd-95d6-61133dec7e34
Local pid:
pubs:648027
Paper number:
16

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