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The effect of sodium nitroprusside on psychotic symptoms and spatial working memory in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial

Abstract:

Sodium nitroprusside (SNP) has been reported to rapidly reduce psychotic symptoms in patients with schizophrenia. This has the potential to revolutionize treatment for schizophrenia. In this study, we tested the hypothesis that SNP leads to a reduction in psychotic symptoms and an improvement in spatial working memory (SWM) performance in patients with schizophrenia.This was a single-centre, randomized, double-blind, placebo-controlled trial performed from 27 August 2014 to 10 February 2016 (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1017/S0033291716002245

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Grant:
Biomedical ResearchCentreforMentalHealthattheSouth London
MaudsleyNHSFoundationTrust
InstituteofPsychiatry,King’sCollegeLondon
Publisher:
Cambridge University Press Publisher's website
Journal:
Psychological Medicine Journal website
Volume:
46
Issue:
16
Pages:
3443-3450
Publication date:
2016-09-22
Acceptance date:
2016-08-04
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
Pmid:
27655012
Source identifiers:
648027
Language:
English
Keywords:
Pubs id:
pubs:648027
UUID:
uuid:185cbc27-c6e9-40fd-95d6-61133dec7e34
Local pid:
pubs:648027
Deposit date:
2016-11-01

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