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Journal article

Impact of lipoprotein(a) levels and apolipoprotein(a) isoform size on risk of coronary heart disease

Abstract:

Observational and genetic studies have shown that lipoprotein(a) [Lp(a)] levels and apolipoprotein(a) [apo(a)] isoform size are both associated with coronary heart disease (CHD) risk, but the relative independence of these risk factors remains unclear. Clarification of this uncertainty is relevant to the potential of future Lp(a)-lowering therapies for the prevention of CHD. Methods: Plasma Lp(a) levels and apo(a) isoform size, estimated by the number of kringle IV (KIV) repeats, were measure...

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Publisher copy:
10.1111/joim.12187

Authors


Hopewell, JC More by this author
Seedorf, U More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Kyriakou, T More by this author
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Publisher:
Blackwell Publishing Ltd
Journal:
Journal of Internal Medicine
Volume:
276
Issue:
3
Pages:
260-268
Publication date:
2014
DOI:
EISSN:
1365-2796
ISSN:
0954-6820
URN:
uuid:18289a64-fc77-49e5-8b52-97f8ecaacf2f
Source identifiers:
480715
Local pid:
pubs:480715

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