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Novel high-throughput screening method using quantitative PCR to determine the antimicrobial susceptibility of Orientia tsutsugamushi clinical isolates

Abstract:
Objectives To develop a method to enable the large-scale antimicrobial susceptibility screening of Orientia tsutsugamushi clinical isolates, using one timepoint and one concentration of antibiotics to considerably speed up the time to result. Methods Growth, harvesting, multiplicity of infection (moi) and the day to determine the MICs were optimized using five O. tsutsugamushi reference strains [susceptible (Karp, Kato and Gilliam) and putatively resistant (... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/jac/dky402

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-0734-2022
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Antimicrobial Chemotherapy Journal website
Volume:
74
Issue:
1
Pages:
74–81
Publication date:
2018-10-06
Acceptance date:
2018-09-05
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Pubs id:
pubs:929657
URN:
uri:1820886f-9d4a-42e0-be03-c6183279b71b
UUID:
uuid:1820886f-9d4a-42e0-be03-c6183279b71b
Local pid:
pubs:929657

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