Journal article
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
- Abstract:
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Several vaccines have demonstrated efficacy against SARS-CoV-2 mediated disease, yet there is limited data on the immune response induced by heterologous vaccination regimens using alternate vaccine modalities. Here, we present a detailed description of the immune response, in mice, following vaccination with a self-amplifying RNA (saRNA) vaccine and an adenoviral vectored vaccine (ChAdOx1 nCoV-19/AZD1222) against SARS-CoV-2. We demonstrate that antibody responses are higher in two-dose heter...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 1.9MB)
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- Publisher copy:
- 10.1038/s41467-021-23173-1
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 12
- Issue:
- 1
- Article number:
- 2893
- Publication date:
- 2021-05-17
- Acceptance date:
- 2021-04-19
- DOI:
- EISSN:
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2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1176673
- Local pid:
- pubs:1176673
- Deposit date:
- 2021-05-17
Terms of use
- Copyright holder:
- AJ Spencer et al.
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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