Journal article icon

Journal article

Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Abstract:

Several vaccines have demonstrated efficacy against SARS-CoV-2 mediated disease, yet there is limited data on the immune response induced by heterologous vaccination regimens using alternate vaccine modalities. Here, we present a detailed description of the immune response, in mice, following vaccination with a self-amplifying RNA (saRNA) vaccine and an adenoviral vectored vaccine (ChAdOx1 nCoV-19/AZD1222) against SARS-CoV-2. We demonstrate that antibody responses are higher in two-dose heter...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-021-23173-1

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
ORCID:
0000-0001-7958-6961
More by this author
Role:
Author
ORCID:
0000-0001-5195-6254
Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Issue:
1
Article number:
2893
Publication date:
2021-05-17
Acceptance date:
2021-04-19
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1176673
Local pid:
pubs:1176673
Deposit date:
2021-05-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP