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Monitoring of large randomised clinical trials: a new approach with Bayesian methods.

Abstract:

BACKGROUND: In judging whether or not to continue enrolling patients into a randomised clinical trial, most data-monitoring and ethics committees (DMECs) rely on the p value for the difference in effect between the study groups. In the 1990s, two randomised controlled trials-one in patients with lung cancer and one in those with head and neck cancer-were instead monitored by Bayesian methods. We assessed the value of this approach in the monitoring of these clinical trials. METHODS: Before t...

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Publication status:
Published

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Authors


Parmar, MK More by this author
Griffiths, GO More by this author
Spiegelhalter, DJ More by this author
Souhami, RL More by this author
Altman, DG More by this author
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Journal:
Lancet
Volume:
358
Issue:
9279
Pages:
375-381
Publication date:
2001-08-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:17f5dc42-52f4-400e-80a8-30c95ec80299
Source identifiers:
317823
Local pid:
pubs:317823

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