BACKGROUND: In judging whether or not to continue enrolling patients into a randomised clinical trial, most data-monitoring and ethics committees (DMECs) rely on the p value for the difference in effect between the study groups. In the 1990s, two randomised controlled trials-one in patients with lung cancer and one in those with head and neck cancer-were instead monitored by Bayesian methods. We assessed the value of this approach in the monitoring of these clinical trials. METHODS: Before t...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Monitoring of large randomised clinical trials: a new approach with Bayesian methods.
If you are the owner of this record, you can report an update to it here: Report update to this record