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Monitoring of large randomised clinical trials: a new approach with Bayesian methods.

Abstract:

BACKGROUND: In judging whether or not to continue enrolling patients into a randomised clinical trial, most data-monitoring and ethics committees (DMECs) rely on the p value for the difference in effect between the study groups. In the 1990s, two randomised controlled trials-one in patients with lung cancer and one in those with head and neck cancer-were instead monitored by Bayesian methods. We assessed the value of this approach in the monitoring of these clinical trials. METHODS: Before t...

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Publication status:
Published

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Journal:
Lancet
Volume:
358
Issue:
9279
Pages:
375-381
Publication date:
2001-08-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:17f5dc42-52f4-400e-80a8-30c95ec80299
Source identifiers:
317823
Local pid:
pubs:317823

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