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111In-labelled polymeric nanoparticles incorporating a ruthenium-based radiosensitizer for EGFR-targeted combination therapy in oesophageal cancer cells

Abstract:

Radiolabelled, drug-loaded nanoparticles may combine the theranostic properties of radionuclides, the controlled release of chemotherapy and cancer cell targeting. Here, we report the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles surface conjugated to DTPA-hEGF (DTPA = diethylenetriaminepentaacetic acid, hEGF = human epidermal growth factor) and encapsulating the ruthenium-based DNA replication inhibitor and radiosensitizer Ru(phen)2(tpphz)2+ (phen = 1,10-phenanthroline, t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/C7NR09606B

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
Jarman, PJ More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
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Funding agency for:
Gill, MR
More from this funder
Funding agency for:
Vallis, KA
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Nanoscale Journal website
Volume:
10
Issue:
22
Pages:
10596-10608
Publication date:
2018-05-29
Acceptance date:
2018-04-17
DOI:
ISSN:
2040-3364
Pubs id:
pubs:843868
URN:
uri:17f336e2-5243-4e39-9ecf-35e3f880bb17
UUID:
uuid:17f336e2-5243-4e39-9ecf-35e3f880bb17
Local pid:
pubs:843868

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