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Laboratory-acquired scrub typhus and murine typhus infections: The argument for risk-based approach to biosafety requirements for Orientia tsutsugamushi and Rickettsia typhi laboratory activities

Abstract:

This study examined the literature on laboratory-acquired infections (LAIs) associated with scrub typhus (Orientia tsutsugamushi) and murine typhus (Rickettsia typhi) research to provide an evidence base for biosafety and biocontainment. Scrub typhus LAIs were documented in 25 individuals, from 1931-2000 with 8 (32%) deaths during the pre-antibiotic era. There were 35 murine typhus LAI reports and no deaths. Results indicated that highest risk activities were working with infectious laborator...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/cid/ciy675

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-6576-726X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-1187-2712
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-0734-2022
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-2309-1171
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Publication date:
2018-08-10
Acceptance date:
2018-08-08
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pubs id:
pubs:909858
URN:
uri:17d020c1-e342-45af-8c3d-573e6a373b6e
UUID:
uuid:17d020c1-e342-45af-8c3d-573e6a373b6e
Local pid:
pubs:909858

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