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Synthesis and in vitro antimicrobial SAR of benzyl and phenyl guanidine and aminoguanidine hydrazone derivatives

Abstract:

A series of benzyl, phenyl guanidine, and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were determined. Several compounds showed potent inhibitory activity against the bacterial strains evaluated, with minimal inhibitory concentration (MIC) values in the low µg/mL range. Of all guanidine derivatives, 3-[2-chloro-3-(trifluoromethyl)]-benzyloxy deriva...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/molecules28010005

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
University College
Role:
Author
ORCID:
0000-0003-3255-9135
Publisher:
MDPI
Journal:
Molecules More from this journal
Volume:
28
Issue:
1
Article number:
5
Publication date:
2022-12-20
Acceptance date:
2022-12-15
DOI:
EISSN:
1420-3049
Language:
English
Keywords:
Pubs id:
1315299
Local pid:
pubs:1315299
Deposit date:
2022-12-19

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