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Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation.

Abstract:

Oxazoline mono-, di-, tri- and hexasaccharides, corresponding to the core components of N-linked glycoprotein high mannose glycans, are synthesised as potential glycosyl donors for endohexosaminidase catalysed glycosylation of glycopeptides and glycoprotein remodelling. The crucial beta-D-Manp-(1-->4)-D-GlcpNAc linkage is synthesised via epimerisation of gluco disaccharide substrates by sequential triflation and nucleophilic substitution. Oxazolines are formed directly from the anomeric OP...

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Publication status:
Published

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Journal:
Carbohydrate research
Volume:
341
Issue:
10
Pages:
1574-1596
Publication date:
2006-07-01
DOI:
EISSN:
1873-426X
ISSN:
0008-6215
Source identifiers:
117883
Language:
English
Keywords:
Pubs id:
pubs:117883
UUID:
uuid:1788f38e-fa72-4331-b296-64936d90497a
Local pid:
pubs:117883
Deposit date:
2012-12-19

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