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Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis

Abstract:

Nucleic acids are potent triggers for innate immunity. Double-stranded DNA and RNA adopt different helical conformations, including the unusual Z-conformation. Z-DNA/RNA is recognised by Z-binding domains (ZBDs), which are present in proteins implicated in antiviral immunity. These include ZBP1 (also known as DAI or DLM-1), which induces necroptosis, an inflammatory form of cell death. Using reconstitution and knock-in models, we report that mutation of key amino acids involved in Z-DNA/RNA b...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/embj.201796476

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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Maelfait, J
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Funding agency for:
Maelfait, J
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Grant:
MRC core funding of the MRC Human Immunology Unit
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
36
Issue:
17
Pages:
2529-2543
Publication date:
2017-07-17
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:709525
URN:
uri:1765ae72-4412-4348-bfaf-f443f70d755d
UUID:
uuid:1765ae72-4412-4348-bfaf-f443f70d755d
Local pid:
pubs:709525
Paper number:
17
Language:
English
Keywords:

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