Journal article
Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis
- Abstract:
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Nucleic acids are potent triggers for innate immunity. Double-stranded DNA and RNA adopt different helical conformations, including the unusual Z-conformation. Z-DNA/RNA is recognised by Z-binding domains (ZBDs), which are present in proteins implicated in antiviral immunity. These include ZBP1 (also known as DAI or DLM-1), which induces necroptosis, an inflammatory form of cell death. Using reconstitution and knock-in models, we report that mutation of key amino acids involved in Z-DNA/RNA b...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.5MB)
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- Publisher copy:
- 10.15252/embj.201796476
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Authors
Funding
+ EMBO
More from this funder
Funding agency for:
Maelfait, J
Grant:
Marie Curie Actions (EMBOCOFUND2010, GA-2010-267146
+ European Commission
More from this funder
Funding agency for:
Maelfait, J
Grant:
Marie Curie Actions (EMBOCOFUND2010, GA-2010-267146
+ Medical Research Council
More from this funder
Grant:
MRC core funding of the MRC Human Immunology Unit
Bibliographic Details
- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 36
- Issue:
- 17
- Pages:
- 2529-2543
- Publication date:
- 2017-07-17
- DOI:
- EISSN:
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1460-2075
- ISSN:
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0261-4189
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:709525
- UUID:
-
uuid:1765ae72-4412-4348-bfaf-f443f70d755d
- Local pid:
- pubs:709525
- Deposit date:
- 2017-08-15
Terms of use
- Copyright holder:
- Maelfait et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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