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Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

Abstract:

Cultured human pathogens may differ significantly from source populations. To investigate the genetic basis of laboratory adaptation in malaria parasites, clinical Plasmodium falciparum isolates were sampled from patients and cultured in vitro for up to three months. Genome sequence analysis was performed on multiple culture time point samples from six monoclonal isolates, and single nucleotide polymorphism (SNP) variants emerging over time were detected. Out of a total of five positively sel...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep41303

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Department:
St Johns College
Claessens, A More by this author
Assefa, SA More by this author
Conway, DJ More by this author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
41303
Publication date:
2017-01-05
Acceptance date:
2016-12-19
DOI:
ISSN:
2045-2322
Pubs id:
pubs:667986
URN:
uri:1760dc54-6879-4b9f-b43a-3f780a1d4b7a
UUID:
uuid:1760dc54-6879-4b9f-b43a-3f780a1d4b7a
Local pid:
pubs:667986

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