Association between hemagglutinin stem-reactive antibodies and influenza A/H1N1 virus infection during the 2009 pandemic.

Journal article

The discovery of influenza virus broadly neutralizing (BrN) antibodies prompted efforts to develop universal vaccines. Influenza virus stem-reactive (SR) broadly neutralizing antibodies have been detected by screening antibody phage display libraries. However, studies of SR BrN antibodies in human serum, and their association with natural infection, are limited. To address this, pre- and postpandemic sera from a prospective community cohort study in Vietnam were assessed for antibodies that i...

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Authors: Hoa, L; Mai, L; Bryant, J; Thai, P; Hang, N

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Society for Microbiology
• Journal: Journal of Virology
• Volume: 90
• Issue: 14
• Pages: 6549-6556
• Publication date: 2016-05-01
• Acceptance date: 2016-04-24
• DOI: 10.1128/jvi.00093-16
• EISSN: 1098-5514
• ISSN: 0022-538X
• Pmid: 27170747
• Language: English
• Keywords: Child; Adolescent; Adult; Ferrets; Infant, Newborn; Aged; Animals; Influenza A Virus, H1N1 Subtype; Infant; Time Factors; Aged, 80 and over; Mice; Antibodies, Monoclonal; Middle Aged; Vietnam; Hemagglutinin Glycoproteins, Influenza Virus; Pandemics; Child, Preschool; Prospective Studies; Influenza, Human; Young Adult; Antibodies, Viral; Female; Hemagglutination Inhibition Tests; Male; Antibodies, Neutralizing; Humans