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Genome-wide association study reveals genetic link between diarrhea-associated Entamoeba histolytica infection and inflammatory bowel disease

Abstract:

Entamoeba histolytica is the etiologic agent of amebic dysentery, though clinical manifestation of infection is highly variable ranging from subclinical colonization to invasive disease. We hypothesize that host genetics contribute to the variable outcomes of E. histolytica infection; thus, we conducted a genome-wide association study (GWAS) in two independent birth cohorts of Bangladeshi infants monitored for susceptibility to E. histolytica disease in the first year of life. Children with a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/mbio.01668-18

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ORCID:
0000-0001-7206-8088
Abhyankar, MM More by this author
Yoshida, N More by this author
Watanabe, K More by this author
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Wellcome Trust More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
mBio Journal website
Volume:
9
Issue:
5
Pages:
e01668-18
Publication date:
2018-09-18
Acceptance date:
2018-08-09
DOI:
EISSN:
2150-7511
ISSN:
2150-7511
Pubs id:
pubs:920820
URN:
uri:1729f562-b6e6-42f9-97e2-78c744866262
UUID:
uuid:1729f562-b6e6-42f9-97e2-78c744866262
Local pid:
pubs:920820

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