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Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

Abstract:

Rheumatoid arthritis is a chronic inflammatory disease that leads to significant changes in metabolic activity. Succinate, an intermediate of the tricarboxylic acid cycle, has emerged as a metabolic mediator of the innate immune response. However, the involvement of succinate in the generation of the adaptive immune response and establishment of autoimmune response has not been addressed thus far. Here we demonstrated that the succinate-sensing receptor (Sucnr1/GPR91) plays a critical role in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1096/fj.201800285

Authors


Saraiva, AL More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
de Lima, KA More by this author
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Publisher:
Federation of American Society of Experimental Biology Publisher's website
Journal:
FASEB Journal Journal website
Volume:
32
Issue:
12
Pages:
6550-6558
Publication date:
2018-06-12
Acceptance date:
2018-05-21
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Pubs id:
pubs:857143
URN:
uri:17092fb0-b24d-4e5f-9d2b-58fc43090005
UUID:
uuid:17092fb0-b24d-4e5f-9d2b-58fc43090005
Local pid:
pubs:857143
Language:
English
Keywords:

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