- Abstract:
-
Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation which leads to joint destruction. Little is known about fibroblast heterogeneity or if aberrations in fibroblast subsets relate to pathology. Here, we show functional and transcriptional differences between fibroblast subsets from human synovial tissues using bulk transcriptomics of targeted subpopulations and s...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Version of record
- Files:
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(pdf, 4.8MB)
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- Publisher copy:
- 10.1038/s41467-018-02892-y
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Issue:
- 789
- Publication date:
- 2018-02-23
- Acceptance date:
- 2018-01-08
- DOI:
- EISSN:
-
2041-1723
- Pubs id:
-
pubs:835738
- URN:
-
uri:16a3f778-a07d-4dfc-b46d-33d06501651c
- UUID:
-
uuid:16a3f778-a07d-4dfc-b46d-33d06501651c
- Local pid:
- pubs:835738
- Language:
- English
- Keywords:
- Copyright holder:
- Fumitaka et al.
- Copyright date:
- 2018
- Notes:
-
Open Access. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/
licenses/by/4.0/.
Journal article
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
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