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Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

Abstract:

Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation which leads to joint destruction. Little is known about fibroblast heterogeneity or if aberrations in fibroblast subsets relate to pathology. Here, we show functional and transcriptional differences between fibroblast subsets from human synovial tissues using bulk transcriptomics of targeted subpopulations and s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
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Publisher copy:
10.1038/s41467-018-02892-y

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
AZ KIR
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
789
Publication date:
2018-02-23
Acceptance date:
2018-01-08
DOI:
EISSN:
2041-1723
Pubs id:
pubs:835738
URN:
uri:16a3f778-a07d-4dfc-b46d-33d06501651c
UUID:
uuid:16a3f778-a07d-4dfc-b46d-33d06501651c
Local pid:
pubs:835738
Language:
English
Keywords:

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