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Thesis

Telomerase-targeting radiopharmaceuticals for the selective treatment of cancer

Abstract:

Background

Telomerase is a ribonucleoprotein that is expressed in the majority of malignancies, whilst being largely absent in differentiated tissue. Previous research has shown that short-term inhibition of telomerase can lead to radiosensitisation of cancer cells. It has been shown previously that enhanced retention and nuclear localisation of transfected Indium-111(111In)-labelled oligonucleotides, targeted to the RNA template of telomerase (hTR), resulted in a ...

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Bas Bavelaar More by this author

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Role:
Supervisor
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Funding agency for:
Bas Bavelaar
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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