Telomerase-targeting radiopharmaceuticals for the selective treatment of cancer

Thesis

Background

Telomerase is a ribonucleoprotein that is expressed in the majority of malignancies, whilst being largely absent in differentiated tissue. Previous research has shown that short-term inhibition of telomerase can lead to radiosensitisation of cancer cells. It has been shown previously that enhanced retention and nuclear localisation of transfected Indium-111(¹¹¹In)-labelled oligonucleotides, targeted to the RNA template of telomerase (hTR), resulted in a ...

Expand abstract

Authors: Bavelaar, B

• DOI: 10.5287/ora-9g9zxymev
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: targeted radionuclide therapy; oncology; radiopharmaceuticals; telomerase