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Hypertension, a dementia polygenic risk score, APOE genotype and incident dementia

Abstract:

Introduction There is inconsistent evidence on whether genetic risk for dementia modifies the association between hypertension and dementia. Methods In 198,965 dementia-free participants aged ≥60 years, Cox proportional-hazards models were used to investigate the association between hypertension and incident dementia. A polygenic risk score (PRS) based on 38 non-apolipoprotein E (APOE) single nucleotide polymorphisms and APOE ε4 status were used to determine genetic risk for dementia. Resul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/alz.12680

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
Publisher:
Wiley
Journal:
Alzheimer's and Dementia: The Journal of the Alzheimer's Association More from this journal
Volume:
19
Issue:
2
Pages:
467-476
Publication date:
2022-04-19
Acceptance date:
2022-03-18
DOI:
EISSN:
1552-5279
ISSN:
1552-5260
Language:
English
Keywords:
Pubs id:
1249349
Local pid:
pubs:1249349
Deposit date:
2022-04-03

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