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HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

Abstract:

Homozygous lymphoblastoid cell lines representing Dw subtypes of the DR2 serotype were studied for structural polymorphism at DR beta. These subtypes included Dw2, Dw12, and non-Dw2/non-Dw12. Analysis by two-dimensional gel electrophoresis showed that two DR beta genes were expressed in each cell line studied. One of these expressed genes encoded a protein that was nonpolymorphic on two-dimensional gel electrophoresis among all subtypes. The second expressed DR beta gene was polymorphic and m...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.84.13.4591

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
McDevitt, HO More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
84
Issue:
13
Pages:
4591-4595
Publication date:
1987-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:162cb712-0850-48ee-b86b-0211ccdef1f9
Source identifiers:
42720
Local pid:
pubs:42720

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