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The meaning of LIF the role of leukaemia inhibitory factor in prostate cancer-induced bone disease

Abstract:

Bone metastasis is a frequent complication of advanced prostate carcinoma (PCa) and there is an urgent need to elucidate the mechanisms that drive metastasis to identify novel therapeutics and biomarkers. Leukaemia inhibitory factor (LIF) is an IL-6 family cytokine known to be involved in a wide range of biological functions including haematopoiesis and bone formation. Moreover, it has shown to be overexpressed in a number of tumour types including those, which metastasise to bone, but th...

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Christina Jane Turner More by this author

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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