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Journal article

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Abstract:
Aims/hypothesis Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds mitochondrial anaplerotic pathways, driving citrate export and cytosolic malonyl-CoA production by the acetyl-CoA carboxylase 1 (ACC1) enzyme. This pathway has been proposed as an alternative glucose-sensing mechanism, supporte... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1007/s00125-018-4743-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
St Peter's College
Role:
Author
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Funding agency for:
Cantley, J
More from this funder
Funding agency for:
Nemes, NJ
Publisher:
Springer Verlag Publisher's website
Journal:
Diabetologia Journal website
Volume:
62
Issue:
1
Pages:
99–111
Publication date:
2018-10-17
Acceptance date:
2018-08-22
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Pubs id:
pubs:929823
URN:
uri:15d65a93-d975-43c5-a962-f7b62d10c17b
UUID:
uuid:15d65a93-d975-43c5-a962-f7b62d10c17b
Local pid:
pubs:929823

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