Journal article icon

Journal article

Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis

Abstract:

The adult neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is unmistakeable from clinical descriptions now more than a century old.1 Neither the site of symptom onset in ALS2 nor pattern of symptom spread3–5 is truly random. While the most consistent signs relate to motor system dysfunction, it is recognised that ALS represents an anatomically widespread neocortical disease,6 involving significant pathological and genetic overlap with Frontotemporal Dementia (FTD).7 8 Nearly ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1136/jnnp-2017-317245

Authors


Henderson, RD More by this author
Kiernan, MC More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
ORCID:
0000-0003-0267-3180
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Nuerology, Neurosurgery & Psychiatry Journal website
Volume:
2019
Issue:
90
Pages:
570-575
Publication date:
2018-04-17
Acceptance date:
2018-03-29
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pubs id:
pubs:835028
URN:
uri:15c0e2c4-8e93-49d2-8615-7b91bb5cf2f8
UUID:
uuid:15c0e2c4-8e93-49d2-8615-7b91bb5cf2f8
Local pid:
pubs:835028

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP