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ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules

Abstract:

Correct orientation of cell division is considered an important factor for the achievement of normal brain size, as mutations in genes that affect this process are among the leading causes of microcephaly. Abnormal spindle orientation is associated with reduction of the neuronal progenitor symmetric divisions, premature cell cycle exit, and reduced neurogenesis. This mechanism has been involved in microcephaly resulting from mutation of ASPM, the most frequently affected gene in autosomal rec...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.15252/embr.201541823

Authors


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ORCID:
0000-0002-8385-3310
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy & Genetics
Bonaccorsi, S More by this author
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Reports Journal website
Volume:
17
Issue:
10
Pages:
1396-1409
Publication date:
2016-08-25
Acceptance date:
2016-07-26
DOI:
ISSN:
1469-3178 and 1469-221X
Pubs id:
pubs:662153
URN:
uri:15741a11-c19d-4f4a-a1c1-415a792db478
UUID:
uuid:15741a11-c19d-4f4a-a1c1-415a792db478
Local pid:
pubs:662153

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