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The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses

Abstract:

Outcome from tuberculous meningitis (TBM) is believed to be dependent on the severity of the intracerebral inflammatory response. We have recently shown that dexamethasone improved survival in adults with TBM and postulated that the clinical effect would be associated with a measurable systemic and intracerebral impact on immunological markers of inflammation. Prolonged inflammatory responses were detected in all TBM patients irrespective of treatment assignme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.175.1.579

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
American Association of Immunologists
Journal:
Journal of Immunology More from this journal
Volume:
175
Issue:
1
Pages:
579-590
Publication date:
2005-06-21
Acceptance date:
2005-04-14
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pmid:
15972695
Language:
English
Keywords:
Pubs id:
pubs:33141
UUID:
uuid:14d58f56-b4ce-4d31-954e-ba90f8bf0bfa
Local pid:
pubs:33141
Source identifiers:
33141
Deposit date:
2017-07-19

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