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Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium

Abstract:

Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on pre-diagnosis androgen concentrations and EOC risk has yielded inconclusive results, and analyses incorporating EOC subtypes are sparse. We conducted a pooled analysis...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1158/0008-5472.CAN-16-3322

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Grant:
Ovarian Cancer Research Program Grant No. W81XWH-12-1-0561
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Grant:
R01 CA163018, UM1 CA186107, R01 CA49449, P01 CA87969, UM1 CA17672, R01 CA098661, UM1 CA182934, P30 CA016087, P30 ES000260
European Commission More from this funder
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Grant:
14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford
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Grant:
1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
77
Issue:
14
Pages:
3951-3960
Publication date:
2017-04-05
Acceptance date:
2017-03-31
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Pubs id:
pubs:688787
URN:
uri:14cbbc70-4165-46c7-84c4-d77050f37c1e
UUID:
uuid:14cbbc70-4165-46c7-84c4-d77050f37c1e
Local pid:
pubs:688787
Paper number:
14

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