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Metabolomic profiling in acute ST‐segment–elevation myocardial infarction identifies succinate as an early marker of human ischemia–reperfusion injury

Abstract:
Background Ischemia–reperfusion injury following ST‐segment–elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia–reperfusion injury; however, the potential importance and specificity of myocardial succinate accumulation in human STEMI is unknown. We sought to identify the metabolites released from the heart in... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/JAHA.117.007546

Authors


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Role:
Author
ORCID:
0000-0003-0069-3276
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
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Grant:
BHF Chair Award CH/16/1/32013
NIHR Oxford Biomedical Research Centre More from this funder
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Grant:
ITN RADOX grant (PITN-GA2012-316738
Publisher:
American Heart Association Publisher's website
Journal:
Journal of the American Heart Association Journal website
Volume:
7
Issue:
8
Article number:
e007546
Publication date:
2018-04-06
Acceptance date:
2018-02-26
DOI:
ISSN:
2047-9980
Pmid:
29626151
Source identifiers:
835417
Language:
English
Keywords:
Pubs id:
pubs:835417
UUID:
uuid:147f3a90-432b-41be-99d6-530206ad01f6
Local pid:
pubs:835417
Deposit date:
2018-09-04

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