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Journal article

Personalized proteome profiles of healthy and tumor human colon organoids reveal both individual diversity and generic features of colorectal cancer

Abstract:

Diseases at the molecular level are complex and patient‐dependent necessitating development of strategies that enable precision treatment to optimize clinical outcomes. Organoid technology has recently been shown to have the potential to recapitulate the in vivo characteristics of the original individual’s tissue in a three dimensional in vitro culture system. Here, we present a quantitative mass spectrometry based proteomic analysis and a comparative transcriptomic analysis of human colorect...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2016.12.016

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
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Stichting Virtutis Opus More from this funder
More from this funder
Funding agency for:
Mohammed, S
Grant:
700.10.429
Stichting Vrienden van het Hubrecht More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
18
Issue:
1
Pages:
263–274
Publication date:
2017-01-01
Acceptance date:
2016-11-29
DOI:
ISSN:
2211-1247
Source identifiers:
664141
Keywords:
Pubs id:
pubs:664141
UUID:
uuid:14752345-ab30-462a-bd18-a66b5772cfaf
Local pid:
pubs:664141
Deposit date:
2016-12-05

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