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Journal article

Personalized proteome profiles of healthy and tumor human colon organoids reveal both individual diversity and generic features of colorectal cancer

Abstract:

Diseases at the molecular level are complex and patient‐dependent necessitating development of strategies that enable precision treatment to optimize clinical outcomes. Organoid technology has recently been shown to have the potential to recapitulate the in vivo characteristics of the original individual’s tissue in a three dimensional in vitro culture system. Here, we present a quantitative mass spectrometry based proteomic analysis and a comparative transcriptomic analysis of human colorect...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2016.12.016

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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
Cristobal, A More by this author
van den Toorn, HWP More by this author
van de Wetering, M More by this author
Clevers, H More by this author
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Stichting Virtutis Opus More from this funder
Stichting Vrienden van het Hubrecht More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
18
Issue:
1
Pages:
263–274
Publication date:
2017-01-05
Acceptance date:
2016-11-29
DOI:
ISSN:
2211-1247
Pubs id:
pubs:664141
URN:
uri:14752345-ab30-462a-bd18-a66b5772cfaf
UUID:
uuid:14752345-ab30-462a-bd18-a66b5772cfaf
Local pid:
pubs:664141
Keywords:

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